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Used - Very Good. Former Library book. Review Article Open Access. Tomonori Takazawa Corresponding Author E-mail address: takazawt gunma-u. Search for more papers by this author. Tools Request permission Export citation Add to favorites Track citation. Share Give access Share full text access. Share full text access. Please review our Terms and Conditions of Use and check box below to share full-text version of article.

Anaphylaxis, Chemical Immunology and Allergy, Vol. 95 | World Allergy Organization

Introduction Anaphylaxis is defined as a serious allergic reaction with a rapid onset, which can be fatal. Epidemiology The incidence rate of anaphylaxis has increased during the last decade. Author, location, year of publication Study period Age group No. Drugs 25 Figure 1 Open in figure viewer PowerPoint.

Immediate management

Vertical bars represent standard error of the means. Figure 2 Open in figure viewer PowerPoint. Mechanisms of Anaphylaxis A good understanding of the mechanisms of anaphylaxis is essential for making a proper diagnosis Fig. Figure 3 Open in figure viewer PowerPoint.

How Allergies Work Animation. Understanding Allergic Reaction Immune System Video. Symptom Treatment

Pathogenesis of anaphylaxis: mechanisms and triggers, cells, mediators, and organ systems affected. Diagnosis As mentioned above, diagnosis of anaphylaxis in an ER setting is not easy. Acute onset of an illness within minutes to several hours with involvement of the skin, mucosal tissue, or both e.

Respiratory compromise e. Two or more of the following that occur rapidly after exposure to a likely allergen for that patient minutes to several hours : a.

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Reduced BP or associated symptoms e. Persistent gastrointestinal symptoms e.

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Reduced BP after exposure to a known allergen for that patient minutes to several hours : a. PEF, peak expiratory flow. IgE, immunoglobulin E. Emergency anaphylaxis management algorithm.

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Figure 5 Open in figure viewer PowerPoint. Drugs used for emergency treatment of anaphylaxis, according to age. Management after Discharge After discharge from the hospital, it is important for patients to be able to cope with possible future anaphylactic episodes Fig. Confirmation of Anaphylaxis Trigger s Etiological diagnosis, including confirmation of anaphylaxis trigger s , is essential to avoid future anaphylactic episodes. Conclusions The initial treatment strategy, followed by correct diagnosis, in the emergency room is critical for preventing fatal anaphylaxis.

Conflict of interest None declared. Allergy Clin. Crossref PubMed Google Scholar.