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Molecular and biochemical aspects of the PD-1checkpoint pathway. N Engl J Med ; J Cytol ; Arch Pathol Lab Med ; Fine-needle aspiration biopsy versus core-needle biopsy in diagnosing lung cancer: A systematic review. Curr Oncol ;ee Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer. Indian J Med Res ; Utility and pattern of positivity of p40 in the diagnosis of squamous cell carcinoma of the lung by cytology: The first study on fine needle aspiration smears.

Cytopathology ; Diagnosis of intrathoracic lesions: are sequential fine-needle aspiration FNA and core needle biopsy CNB combined better than either investigation alone? Clin Radiol ; Combining fine-needle aspiration and core biopsy under CT fluoroscopy guidance: A better way to treat patients with lung nodules?

Understanding Your Pathology Report: Lung Cancer

Adenocarcinoma predominant pattern subtyping and nuclear grading in cytology: Is there a role in prognostication of advanced pulmonary adenocarcinomas? Moreira AL. Subtyping of pulmonary adenocarcinoma in cytologic specimens: The next challenge. Cancer Cytopathol ; FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing. National Comprehensive Cancer Network. Objective 3: Pulmonary Hypertension List the structural cardiopulmonary conditions that are frequently associated with pulmonary hypertension.

Objective 4: Conditions Contributing to Pulmonary Hypertension Explain how each of the following cardiopulmonary conditions contributes to pulmonary hypertension: increased pulmonary blood flow or pressure, increased pulmonary vascular resistance, or left heart resistance to blood flow. Objective 5: Goodpasture Syndrome and Granulomatosis with Polyangiitis Wegener Granulomatosis Compare and contrast the clinical manifestations, pathogenesis, and pathologic findings in Goodpasture syndrome and granulomatosis with polyangiitis Wegener granulomatosis.

Goal 6: Pulmonary Infection Apply knowledge of the local pulmonary defense mechanisms and systemic host resistance to infection to discuss pathogenesis, classification, clinical manifestations, and pathologic findings in lower respiratory tract infections in immunocompetent and immunocompromised hosts. Objective 1: Classification of Pneumonia by Agent Describe the classification of pneumonias by clinical setting and name the common etiologic agents for each category.

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Objective 2: Clinical Features of Pneumonia Compare and contrast the clinical presentation and manifestations, gross and microscopic pathology, prognosis, and potential complications for each category of pneumonias. Objective 5: Aspiration Pneumonia Name risk factors for aspiration pneumonia and describe the pathology, prognosis, and potential complications. Objective 6: Lung Abscess Define lung abscess in terms of pathogenesis, typical microorganisms, clinical presentation and course, and pathologic findings.

Objective 7: Fungal Pneumonia Compare and contrast the causative agents, geographic locations, clinical presentation, and pathologic findings in chronic pneumonia caused by fungal organisms. Objective 9: Features of Pulmonary Infections in the Immune-compromised and Immunocompetent Discuss the differences in clinical presentation and etiologic agents of pneumonia in immunocompetent versus immunocompromised hosts. Goal 7: Lung Neoplasia Apply knowledge of the molecular basis of neoplasia to describe clinical presentation, biologic behavior, morphologic appearance, classification, diagnosis, prognosis and targeted therapy of lung neoplasms.

Objective 1: Lung Neoplasms Describe the common locations and clinical presentation for the different types of lung cancer. Objective 2: Morphologic Features of Lung Neoplasms Identify key gross and histopathologic features that help differentiate between small cell, adenocarcinoma, and squamous cell carcinoma. Objective 3: Metastatic Carcinoma to the Lung Describe features that favor the diagnosis of metastatic carcinoma over a primary lung tumor. Objective 4: Genetics of Lung Cancer Describe the contribution of specific genetic mutations that contribute to particular lung cancers and explain how these mutations affect therapeutic decisions.

Objective 5: Environmental Factors Predisposing to Lung Cancer Explain the environmental factors that predispose to the development of lung cancer and illustrate how these factors interact with genetic factors in the development of cancer. Duke Anatomy. Duke Embryology.

Duke Histology. Duke Neuro. UMich Basic Path. UMich Pathology. Summary of Gross Findings The lungs were remarkable for a 5 cm mass in the right upper lobe. The cut surfaces were friable and yellowish-gray. Regional lymph nodes were filled with similar necrotic tumor. Summary of Microscopic Findings The tumor tissue consists of glandular structures with very large nuclei which are often arranged in several layers. The nuclear to cytoplasmic ratio is low. There are several mitoses and the stroma contains increased amounts of collagen. Well differentiated adenocarcinomas, with a glandular pattern like this one, are uncommon in the lung.

Review Lung Histology Norm No. Review Lung Anatomy Norm No. Summary of Radiologic Findings The first image is a contrast-enhanced CT of the chest that shows a large mass in the left lung and left hilum. The second image is a CT of the abdomen that shows multiple lucent lesions consistent with metastatic carcinoma. Summary of Microscopic Findings The cytologic specimens show clusters of atypical cells with minimal cytoplasm.

Types of Lung Cancer | LUNGevity Foundation

There is nuclear molding. The chromatin is mostly fine without a large nucleolus. The histologic section shows a portion of lung with a focus of bronchial cartilage and respiratory epithelium as well as minimal normal lung parenchyma.

Tumors of the Lungs (Step 1 and 2)

There is a mass lesion composed of an infiltrative population of small hyperchromatic cells with minimal cytoplasm. Mitotic figures are readily apparent. Higher magnification shows fine chromatin and nuclear molding.

Medical information provided on this site is for informational and educational purposes only. After reading content from this website, you are encouraged to review the information carefully with your physician. All rights reserved. Google Tag Manager. Classification by histology The different types of lung cancer are described histologically by the types of cells the pathologist sees under the microscope. Other histologic types Among the less common types of lung cancer are sarcomatoid carcinoma, salivary gland tumors, and unclassified carcinomas.